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KMID : 1039420190530060354
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Journal of Pathology and Translational Medicine
2019 Volume.53 No. 6 p.354 ~ p.360
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MicroRNA-374a Expression as a Prognostic Biomarker in Lung Adenocarcinoma
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Kim Ye-Seul
Sim Jong-Min
Kim Hyun-Sung
Bang Seong-Sik
Jee Seung-Yun
Park Sung-Eon
Jang Ki-Seok
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Abstract
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Background: Lung cancer is the most common cause of cancer-related death, and adenocarcinoma is the most common histologic subtype. MicroRNA is a small non-coding RNA that inhibits multiple target gene expression at the post-transcriptional level and is commonly dysregulated in malignant tumors. The purpose of this study was to analyze the expression of microRNA-374a (miR-374a) in lung adenocarcinoma and correlate its expression with various clinicopathological characteristics.
Methods: The expression level of miR-374a was measured in 111 formalin-fixed paraffin-embedded lung adenocarcinoma tissues using reverse transcription-quantitative polymerase chain reaction assays. The correlation between miR-374a expression and clinicopathological parameters, including clinical outcome, was further analyzed.
Results: High miR-374 expression was correlated with advanced pT category (chi-square test, p=.004) and pleural invasion (chi-square test, p=.034). Survival analysis revealed that patients with high miR-374a expression had significantly shorter disease-free survival relative to those with low miR-374a expression (log-rank test, p=.032).
Conclusions: miR-374a expression may serve as a potential prognostic biomarker for predicting recurrence in early stage lung adenocarcinoma after curative surgery.
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KEYWORD
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Lung neoplasms, Adenocarcinoma, Stage, Recurrence, MicroRNAs
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